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doi: 10.3389/fimmu.2015.00386 Received 06 May 2015 Accepted 13 July 2015 Published 27 July 2015 Volume 6 - 2015 Edited by Heidi Noels, Institute for Molecular Cardiovascular Research, Germany Reviewed by Yasuo Terauchi, Yokohama City University, Japan

[43] While their incidence is rare, agranulocytosis, aplastic anemia, hemolytic anemia, leukopenia, and thrombocytopenia have been reported with thiazide diuretic therapy, like hydrochlorothiazide

This technology has fueled a promising therapeutic pipeline, including novel GLP-1/GIP dual agonists with differentiated clinical profiles

ACHIEVE-3: Orforglipron Superior to Semaglutide for Type 2 Diabetes in Phase 3 Trial Orforglipron, an investigational once-daily small molecule oral GLP-1 receptor agonist, has proven its superior safety and efficacy versus oral semaglutide in treating type 2 diabetes (T2D) inadequately controlled with metformin